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Lipoprotein-associated phospholipase A2: A new...
Journal article

Lipoprotein-associated phospholipase A2: A new therapeutic target

Abstract

Lipoprotein-associated phospholipase A2 is an enzyme produced by inflammatory cells, which binds to apolipoprotein B-containing lipoproteins and degrades oxidatively modified phospholipids in low-density lipoprotein cholesterol particles, leading to formation of proinflammatory and cytotoxic products. Experimental studies suggest a role for lipoprotein-associated phospholipase A2 in the formation of advanced rupture-prone atherosclerotic …

Authors

Lonn E

Journal

Canadian Journal of Cardiology, Vol. 26, , pp. 27a–31a

Publisher

Elsevier

Publication Date

March 2010

DOI

10.1016/s0828-282x(10)71058-8

ISSN

0828-282X