Bio-inorganic effects of D-penicillamine in children and in the elderly. Journal Articles

abstract

• The principle mechanisms of action of dimethylcysteine (D-penicillamine) are thiazolidine formation, sulphhydryl -disulphide exchange, chelation and superoxide dismutase-like activity; as a consequence, it can enter into many varied biological interactions. Thiazolidine formation with maturing collagen makes D-penicillamine potentially teratogenic; sulphhydryl -disulphide exchange allows the formation of a mixed disulphide with L-cysteine from the L-cystine dimer; chelation permits it to bind metals such as copper; and superoxide scavenging makes it theoretically capable of influencing the inflammatory response of specific cell systems. Not surprising, D-penicillamine is of value in the treatment of cystinuria, Wilson's disease, juvenile rheumatism, rheumatoid arthritis and various other conditions.

authors

• Kean, WF
• Bellamy, N
• Lock, CJ
• Adachi, Jonathan Derrick

status

• published 

publication date

• 1984

has subject area

• 11 Medical and Health Sciences (FoR)
• Abnormalities, Drug-Induced (MeSH)
• Aged (MeSH)
• Arthritis, Juvenile (MeSH)
• Arthritis, Rheumatoid (MeSH)
• Child (MeSH)
• Cystinuria (MeSH)
• Female (MeSH)
• General Clinical Medicine (Science Metrix)
• Hepatolenticular Degeneration (MeSH)
• Humans (MeSH)
• Infant, Newborn (MeSH)
• Muscular Dystrophies (MeSH)
• Penicillamine (MeSH)
• Pregnancy (MeSH)

published in

• Clinical and Investigative Medicine  Journal

keywords

• Abnormalities, Drug-Induced
• Aged
• Arthritis, Juvenile
• Arthritis, Rheumatoid
• Child
• Cystinuria
• Female
• Hepatolenticular Degeneration
• Humans
• Infant, Newborn
• Muscular Dystrophies
• Penicillamine
• Pregnancy

PubMed ID

• 6723129

start page

• 77

end page

• 83

volume

• 7

issue

• 1