Appropriate target interactions prevent abnormal cytoskeletal changes in neurons: a study with intra-sciatic grafts of the septum and the hippocampus

Transplantation of embryonic CNS regions into the PNS provides an opportunity to study temporal and spatial changes in the cytoskeleton that are associated with aging and neurodegenerative diseases. In this study, the fetal septum was transplanted alone or with the hippocampus into the sciatic nerves of young adult rats to determine whether the proper central neural target could prevent the expression of abnormal cytoskeletal changes. The …