Journal article
Morphology of acute promyelocytic leukemia with cytogenetic or molecular evidence for the diagnosis: Characterization of additional microgranular variants
Abstract
Early diagnosis of t(15;17) acute promyelocytic leukemia (APL) is essential because of the associated disseminated intravascular coagulation and the unique response of the disease to all-trans retinoic acid (ATRA) therapy. Early diagnosis depends primarily on morphological recognition. The French-American-British (FAB) classification, however, does not describe all morphological variations that occur in APL. In 25 cases with evidence of APL …
Authors
Neame PB; Soamboonsrup P; Leber B; Carter RF; Sunisloe L; Patterson W; Orzel A; Bates S; McBride JA
Journal
American Journal of Hematology, Vol. 56, No. 3, pp. 131–142
Publisher
Wiley
Publication Date
November 1997
DOI
10.1002/(sici)1096-8652(199711)56:3<131::aid-ajh1>3.0.co;2-z
ISSN
0361-8609
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAgedAged, 80 and overBlotting, SouthernBone MarrowCell CountChildCytoplasmic GranulesDNA, NeoplasmDisseminated Intravascular CoagulationFemaleHistocytochemistryHumansImmunophenotypingIn Situ Hybridization, FluorescenceKaryotypingLeukemia, Promyelocytic, AcuteMaleMiddle AgedPolymerase Chain ReactionRetrospective Studies