Evidence for D₂ Receptor Regulation of Dopamine Release in the Goldfish Retina Journal Articles

abstract

• AbstractThe possible existence of a dopamine D2 receptor‐mediated regulation of dopamine release was investigated in the goldfish retina. Isolated retinas were preloaded with [3H]dopamine and superfused with D2 dopamine receptor agonists or antagonists to determine if there was an effect on [3H]dopamine release. The D2 receptor antagonist sulpiride increased both baseline [3H]‐ dopamine release and [3H]dopamine release induced by an increase in extracellular potassium concentration. The D2 receptor agonists LY‐171555 and RU‐24213 did not reduce baseline [3H]dopamine release but completely inhibited [3H]dopamine release induced by an increase in [K±]o. This action of the D2 agonists was blocked by sulpiride. These studies demonstrate the existence of D2 receptor, possibly autoreceptor, regulation of dopamine release in the teleost retina.

authors

• Rashid, Kashif
• Baldridge, William H
• Ball, Alexander Keith

status

• published 

publication date

• December 1993

has subject area

• 0601 Biochemistry and Cell Biology (FoR)
• 1109 Neurosciences (FoR)
• Animals (MeSH)
• Autoradiography (MeSH)
• Dopamine (MeSH)
• Dopamine Agents (MeSH)
• Ergolines (MeSH)
• Goldfish (MeSH)
• Immunohistochemistry (MeSH)
• In Vitro Techniques (MeSH)
• Kinetics (MeSH)
• Neurology & Neurosurgery (Science Metrix)
• Potassium (MeSH)
• Quinpirole (MeSH)
• Receptors, Dopamine D2 (MeSH)
• Retina (MeSH)
• Sulpiride (MeSH)
• Time Factors (MeSH)
• Tritium (MeSH)

published in

• Journal of Neurochemistry  Journal

keywords

• Animals
• Autoradiography
• Dopamine
• Dopamine Agents
• Ergolines
• Goldfish
• Immunohistochemistry
• In Vitro Techniques
• Kinetics
• Potassium
• Quinpirole
• Receptors, Dopamine D2
• Retina
• Sulpiride
• Time Factors
• Tritium

Digital Object Identifier (DOI)

• 10.1111/j.1471-4159.1993.tb07438.x

PubMed ID

• 7902419

start page

• 2025

end page

• 2033

volume

• 61

issue

• 6