Background and Purpose: Hemodialysis (HD) is the main form of renal replacement therapy for many patients with end-stage renal disease. The purpose of this research is to assess reliability and validity of the Patient’s Perception of Hemodialysis Scale. Methods: Using a cross-sectional design and a convenient sample (
n= 236), psychometric properties of the PPHS were examined. Validity was assessed using factor analysis and Pearson’s correlation. Reliability was determined using Cronbach’s alpha and test–retest stability ( n= 30). Results: Validity and reliability was supported. Conclusion: Examination of the PPHS provides evidence that it is a valid and reliable instrument for measuring disease-specific concerns with the HD patients, assessing how people experience life, and identifying ways in which people interpret the meaning of their physical and psychosocial health and adaptation to life on HD.