Pilot study to determine the impact of a multidisciplinary educational intervention in patients hospitalized with heart failure Academic Article uri icon

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  • BACKGROUND: Patients with heart failure (HF) face challenges complying with multidrug regimens. OBJECTIVES: To examine the impact of a compliance enhancing intervention on medication compliance and morbidity in HF. DESIGN: Patients were randomized to either usual care or an inhospital educational intervention delivered by a multidisciplinary team (Intervention). SETTING: Acute medical and surgical units at a teaching hospital. PATIENTS: One hundred thirty four patients with a clinical diagnosis of HF and a left ventricular ejection fraction of < 40% requiring long-term medical treatment. MAIN OUTCOME MEASURES: A validated HF-specific instrument provided a measure of knowledge. We characterized patients as noncompliant if pharmacy refill data suggested they had taken < or = 0.80 of their medication. We measured quality of life using the Minnesota Living with Heart Failure Questionnaire and the Short Form 36 and conducted a time to first event analysis of a composite end point including mortality, readmissions, and emergency department visits. RESULTS: The Intervention group showed higher knowledge scores at discharge and 1 year (P = .05). The risk of noncompliance in Intervention patients varied from 0.78 (95% CI 0.33-1.89) for ACE-I (13% Intervention, 17% Control) to 1.02 (0.49-2.12) for diuretics (23% Intervention, 23% Control). Quality of life improved in both groups over time; the only difference between groups favored the Intervention (Minnesota Living with Heart Failure Questionnaire, P = .04). The composite end point occurred in 67% of control and 60% of Intervention patients (hazard ratio 0.85, 95% CI 0.55-1.30). CONCLUSIONS: An inhospital educational intervention improved knowledge and, possibly, quality of life and may be useful as part of a comprehensive compliance enhancing strategy in patients with HF.


  • Gwadry-Sridhar, Femida H
  • Arnold, J Malcolm O
  • Zhang, Ying
  • Brown, James E
  • Marchiori, Gordon
  • Guyatt, Gordon

publication date

  • November 2005