Journal article
Mucosal damage during intestinal anaphylaxis in the rat
Abstract
In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized withNippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epithelial damage with shorter villi, decreased activity of digestive enzymes, decreased levels of mucosal histamine, a mast cell …
Authors
D'Incà R; Hunt RH; Perdue MH
Journal
Digestive Diseases and Sciences, Vol. 37, No. 11, pp. 1704–1708
Publisher
Springer Nature
Publication Date
November 1992
DOI
10.1007/bf01299863
ISSN
0163-2116