The Evolving Epidemiology ofHelicobacter pyloriInfection and Gastric Cancer Journal Articles

abstract

• The relationship betweenHelicobacter pyloriinfection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, the role ofcagAstrains ofH pyloriin relation to gastric cancer has not been evaluated systematically. We undertook a meta-analysis of epidemiological studies examining the relationship between infection withcagA-positive strains ofH pyloriand the risk of gastric cancer, and found that patients who are seropositive forcagAstrains ofH pyloriare at an increased risk for developing noncardia gastric cancer compared with those withH pyloriinfection alone. Therefore, searching forcagA-positive strains ofH pylorimay help identify populations at a greater risk for developing gastric cancer.

authors

• Huang, Jia-Qing
• Hunt, Richard H

status

• published 

publication date

• 2003

has subject area

• Animals (MeSH)
• Antigens, Bacterial (MeSH)
• Bacterial Proteins (MeSH)
• Diagnostic Errors (MeSH)
• Helicobacter Infections (MeSH)
• Helicobacter pylori (MeSH)
• Humans (MeSH)
• Risk Factors (MeSH)
• Stomach Neoplasms (MeSH)

published in

• Canadian Journal of Gastroenterology and Hepatology  Journal

keywords

• Animals
• Antigens, Bacterial
• Bacterial Proteins
• Diagnostic Errors
• Helicobacter Infections
• Helicobacter pylori
• Humans
• Risk Factors
• Stomach Neoplasms

Digital Object Identifier (DOI)

• 10.1155/2003/692808

PubMed ID

• 12845346

start page

• 18B

end page

• 20B

volume

• 17

issue

• suppl b