The efficacy of fluoxetine in improving physical symptoms associated with premenstrual dysphoric disorder Academic Article uri icon

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  • OBJECTIVE: To determine the effectiveness of fluoxetine in alleviating physical symptoms of premenstrual dysphoric disorder. DESIGN: Randomised, double-blind, placebo controlled, parallel study. SETTING: Canadian University based outpatient clinics. Participants Four hundred and five subjects, of whom 320 with prospectively determined premenstrual dysphoric disorder were randomised. METHODS: Randomised women were assigned to fluoxetine 20 or 60 mg/day or placebo. Common physical symptoms associated with premenstrual dysphoric disorder including breast tenderness, bloating, and headache were evaluated by visual analog scales and the self-rated and observer premenstrual tension syndrome scales. OUTCOME MEASURES: Luteal phase change from mean baseline scores to mean treatment scores for all scales. RESULTS: Fluoxetine treatment was statistically superior to placebo, with no significant differences between the two fluoxetine dosages in their effects on physical symptoms. CONCLUSION: Daily fluoxetine treatment is superior to placebo in improving the most common physical symptoms associated with premenstrual dysphoric disorder.


  • Steiner, Meir
  • Romano, Steven J
  • Babcock, Susan
  • Dillon, Julia
  • Shuler, Cathy
  • Berger, Charlene
  • Carter, Diana
  • Reid, Robert
  • Stewart, Donna
  • Steinberg, Susanne
  • Judge, Rajinder

publication date

  • May 2001