The anti‐idiotypic antibody 1F7 selectively inhibits cytotoxic T cells activated in HIV‐1 infection
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abstract
Circulating CD8+ T lymphocyte numbers rise substantially following infection with HIV‐1. This expanded CD8+ T cell population includes HIV‐specific CTL and CTL that kill activated uninfected CD4+ lymphocytes. Experimental, epidemiological and clinical evidence supports the possibility that expansion of CD8+ CTL contributes to CD4+ T cell depletion and disease progression in human HIV infection. Therefore, modulation of CD8+ T cell numbers or of certain CD8+ CTL activated in HIV‐infected individuals may be beneficial. It was found that 1F7, a mAb against an idiotype common to anti‐HIV and anti‐simian immunodeficiency virus (SIV) antibodies, selectively inhibited both anti‐HIV CTL and CTL against uninfected CD4+ T cells. Alloantigen‐specific CTL and NK cells from either HIV‐infected individuals or controls were unaffected by 1F7. Prolonged incubation of CD8+ T cells from HIV‐infected individuals with 1F7 induces apoptosis, which was shown to be reflected functionally in reduced total CTL activity and in especially reduced CTL activity against uninfected CD4+ lymphocytes. The selective reactivity of 1F7 with certain CD8+ CTL could be applied towards the modulation of CD8+ T cell responses involved in AIDS pathogenesis.
