Journal article
Modulation of c-fos expression in the rat striatum by diazepam
Abstract
The benzodiazepine agonist, diazepam, inhibits cAMP production in the rat brain. Since cAMP influences c-fos activity, we examined the effects of diazepam on expression of this immediate early gene, as indicated by Western blot analysis. Intraperitoneal administration of diazepam increased Fos protein levels in the striatum, but not in the hippocampus. In contrast, pretreatment with diazepam blocked the potent inducing effect of amphetamine, in …
Authors
Niles LP; Smith LJ; Tenn CC
Journal
Neuroscience Letters, Vol. 236, No. 1, pp. 5–8
Publisher
Elsevier
Publication Date
October 1997
DOI
10.1016/s0304-3940(97)00755-6
ISSN
0304-3940