Role of oropharyngeal stimulation in cholecystokinin-induced satiety in the sham feeding rat

The belief that oropharyngeal stimulation potentiates the satiety produced by cholecystokinin (CCK) is based on the demonstration that the ability of 20% pure CCK to suppress feeding is enhanced the closer it is injected to a meal. The increase efficacy of CCK with closer temporal proximity to a meal might simply reflect increased peptide levels at the time of feeding. Further, since oropharyngeal synergy has never been demonstrated with pure …