Journal article
The mechanism of altered neural function in a rat model of acute colitis
Abstract
BACKGROUND & AIMS: Distal colitis induced in rats by trinitrobenzene sulfonic acid (TNBS) causes a suppression of [3H]noradrenaline release from the myenteric plexus, of inflamed distal colon, as well as in noninflamed regions of colon and ileum. The aim of this study was to explore the mechanisms underlying these neural changes in TNBS colitis.
METHODS: Colitis was induced by intrarectal administration of TNBS, and the animals were killed on …
Authors
Jacobson K; McHugh K; Collins S
Journal
Gastroenterology, Vol. 112, No. 1, pp. 156–162
Publisher
Elsevier
Publication Date
January 1997
DOI
10.1016/s0016-5085(97)70230-0
ISSN
0016-5085
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute DiseaseAdministration, TopicalAdrenergic FibersAnimalsAnti-Inflammatory AgentsBudesonideColitisColonGlucocorticoidsInterleukin 1 Receptor Antagonist ProteinMaleMiceNorepinephrinePotassium ChloridePregnenedionesPremedicationRatsRats, NudeRats, Sprague-DawleyReceptors, Interleukin-1SialoglycoproteinsTrinitrobenzenesulfonic Acid