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Activation of the stress-activated JNK and p38 MAP...
Journal article

Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy

Abstract

We have examined the possible role of the stress-activated JNK and p38 protein kinases in cellular sensitivity following Photofrin-mediated photodynamic therapy (PDT). Previously we reported that immortalized Li-Fraumeni syndrome (LFS) cells are more resistant to Photofrin-mediated PDT compared to normal human fibroblasts (NHF) at equivalent cellular Photofrin levels. In the current work we report that Photofrin-mediated PDT increased the …

Authors

Tong Z; Singh G; Valerie K; Rainbow AJ

Journal

Journal of Photochemistry and Photobiology B Biology, Vol. 71, No. 1-3, pp. 77–85

Publisher

Elsevier

Publication Date

October 2003

DOI

10.1016/j.jphotobiol.2003.08.001

ISSN

1011-1344