The search for autism disease genes Journal Articles

abstract

• AbstractAutism is a heritable disorder characterized by phenotypic and genetic complexity. This review begins by surveying current linkage, gene association, and cytogenetic studies performed with the goal of identifying autism disease susceptibility variants. Though numerous linkages and associations have been identified, they tend to diminish upon closer examination or attempted replication. The review therefore explores challenges to current methodologies presented by the complexities of autism that might underlie some of the current difficulties, and finishes by describing emerging phenotypic, statistical, and molecular investigational approaches that offer hope of overcoming those challenges. © 2004 Wiley‐Liss, Inc. MRDD Research Reviews 2004;10:272–283.

authors

• Wassink, Thomas H
• Brzustowicz, Linda M
• Bartlett, Christopher W
• Szatmari, Peter

status

• published 

publication date

• November 2004

has subject area

• 1103 Clinical Sciences (FoR)
• Autistic Disorder (MeSH)
• Chromosomes, Human, Pair 2 (MeSH)
• Cytogenetics (MeSH)
• Gene Expression (MeSH)
• Genetic Linkage (MeSH)
• Genetic Predisposition to Disease (MeSH)
• Humans (MeSH)
• Hybridization, Genetic (MeSH)
• Language Disorders (MeSH)
• Neurology & Neurosurgery (Science Metrix)
• Oligonucleotide Array Sequence Analysis (MeSH)
• Phenotype (MeSH)

published in

• Developmental Disabilities Research Reviews  Journal

keywords

• Autistic Disorder
• Chromosomes, Human, Pair 2
• Cytogenetics
• Gene Expression
• Genetic Linkage
• Genetic Predisposition to Disease
• Humans
• Hybridization, Genetic
• Language Disorders
• Oligonucleotide Array Sequence Analysis
• Phenotype

Digital Object Identifier (DOI)

• 10.1002/mrdd.20041

PubMed ID

• 15666342

start page

• 272

end page

• 283

volume

• 10

issue

• 4