Journal article
Free radicals uncouple the sodium pump in pig coronary artery
Abstract
Free radicals may impair vital functions of several types of tissues including coronary artery smooth muscle. Because the Na+ pump plays a key role in maintaining coronary tone, the effects of superoxide and peroxide on this protein were examined. Ouabain-sensitive Rb+ uptake by denuded coronary artery rings was used in lieu of K+ transport by this pump. It was inhibited by exposing the rings for 90 min either to peroxide [50% inhibitory …
Authors
Elmoselhi AB; Butcher A; Samson SE; Grover AK
Journal
American Journal of Physiology, Vol. 266, No. 3, pp. c720–c728
Publisher
American Physiological Society
Publication Date
March 1, 1994
DOI
10.1152/ajpcell.1994.266.3.c720
ISSN
0002-9513