Journal article
Effects of peroxide on endothelial nitric oxide synthase in coronary arteries
Abstract
Reactive oxygen species (ROS) are produced in ischemia and reperfusion. Since endothelial nitric oxide synthase (eNOS) is key to the endothelium- dependent vasodilation, we examined the effects of peroxide on this enzyme. We treated cells cultured from pig coronary artery endothelium with different concentrations of hydrogen peroxide, washed them, solubilized them and measured NOS activity by arginine to citrulline conversion. Hydrogen peroxide …
Authors
Shah KA; Samson SE; Grover AK
Journal
Molecular and Cellular Biochemistry, Vol. 183, No. 1-2, pp. 147–152
Publisher
Springer Nature
Publication Date
June 1998
DOI
10.1023/a:1006828205261
ISSN
0300-8177