Journal article
Genetic markers in mouse teratocarcinoma cells. Selection and partial characterization of mutants resistant to toyocamycin, DRB and podophyllotoxin
Abstract
Stable mutants resistant to a number of cytotoxic drugs, (i) adenosine analog toyocamycin (Toyr); (ii) microtubule inhibitor podophyllotoxin (PodR); and (iii) nucleoside analog 5,6-dichloro-1-β-d-ribofuranosyl benzimidazole (DrbR), have been isolated in the mouse teratocarcinoma cell line OC15S1. Biochemical studies reveal that the genetic lesion in Toyr mutants causes a nearly total deficiency of the enzyme adenosine kinase, which …
Authors
Gupta RS; Hodgson M
Journal
Experimental Cell Research, Vol. 132, No. 2, pp. 496–500
Publisher
Elsevier
Publication Date
4 1981
DOI
10.1016/0014-4827(81)90129-4
ISSN
0014-4827