Journal article
Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line
Abstract
Puromycin-resistant (PurR) mutants/variants of a human carcinoma cell line (HeLa), which show greatly reduced cellular uptake of 3H-puromycin and 3H-daunomycin have been isolated after one- and two-step selections in presence of the drug. The cross-resistance pattern of these mutant cell lines towards numerous anticancer drugs and other inhibitors has been examined. Both the first- and the second-step mutants exhibited increased resistance to a …
Authors
Gupta R; Murray W; Gupta R
Journal
British Journal of Cancer, Vol. 58, No. 4, pp. 441–447
Publisher
Springer Nature
Publication Date
October 1988
DOI
10.1038/bjc.1988.237
ISSN
0007-0920