Journal article
Purification of Recombinant Human Hsp60: Use of a GroEL-free Preparation to Assess Autoimmunity in Rheumatoid Arthritis
Abstract
A 65 kDa mycobacterial heat shock protein has been implicated in the development or perpetuation of the inflammatory diseases rheumatoid arthritis (RA) and insulin dependent diabetes mellitus (IDDM). An homology of the mycobacterial hsp65 with human hsp60 (HuHsp60) has been thought to constitute a cross reactive autoimmunizing pathogenetic potential. Study of this cross reactivity with recombinant reagents has been complicated by the fact that …
Authors
Handley HH; Ngyuen M-D; Yu DTY; Gupta RS; Vaughan JH
Journal
Journal of Autoimmunity, Vol. 8, No. 5, pp. 659–673
Publisher
Elsevier
Publication Date
October 1995
DOI
10.1006/jaut.1995.0049
ISSN
0896-8411