The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy Academic Article uri icon

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abstract

  • RATIONALE: Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. METHODS: In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. RESULTS: Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. CONCLUSIONS: The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.

authors

  • Junge, Kristin M
  • Hörnig, Friederike
  • Herberth, Gunda
  • Röder, Stefan
  • Kohajda, Tibor
  • Rolle-Kampczyk, Ulrike
  • von Bergen, Martin
  • Borte, Michael
  • Simon, Jan-Christoph
  • Heroux, Delia
  • Denburg, Judah Aryeh
  • Lehmann, Irina

publication date

  • May 2014

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