Human Mast Cell and Basophil/Eosinophil Progenitors Journal Articles

abstract

• Mast cell, basophil, and eosinophil lineages all derive from CD34(+) hemopoietic stem cells; however, mast cells are derived from a distinct, nonmyeloid progenitor, while eosinophils and basophils share a common myeloid progenitor. These progenitors likely evolved from an ancestral leukocyte population involved in innate immunity and currently play a central role in the pathology of allergic disease. Advances in isolation and analysis of mast cell and basophil/eosinophil progenitor populations have been critical to understanding lineage commitment, differentiation, function, and transcriptional regulation of these cells and have provided a way of monitoring the effect of novel investigational therapies on these cell populations in samples of blood, bone marrow, and airway secretions.

authors

• Gauvreau, Gail
• Denburg, Judah A

status

• published 

publication date

• 2015

has subject area

• 0399 Other Chemical Sciences (FoR)
• 0601 Biochemistry and Cell Biology (FoR)
• Basophils (MeSH)
• Bone Marrow Cells (MeSH)
• Developmental Biology (Science Metrix)
• Eosinophils (MeSH)
• Fetal Blood (MeSH)
• Flow Cytometry (MeSH)
• Humans (MeSH)
• Mast Cells (MeSH)
• Methylcellulose (MeSH)
• Receptors, Granulocyte-Macrophage Colony-Stimulating Factor (MeSH)
• Receptors, Interleukin-3 (MeSH)
• Receptors, Interleukin-5 (MeSH)
• Sputum (MeSH)
• Stem Cells (MeSH)

published in

• Methods in molecular biology (Clifton, N.J.)  Journal

keywords

• Basophils
• Bone Marrow Cells
• Eosinophils
• Fetal Blood
• Flow Cytometry
• Humans
• Mast Cells
• Methylcellulose
• Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
• Receptors, Interleukin-3
• Receptors, Interleukin-5
• Sputum
• Stem Cells

Digital Object Identifier (DOI)

• 10.1007/978-1-4939-1568-2_4

PubMed ID

• 25388244

start page

• 59

end page

• 68

volume

• 1220