Erythrocytotoxicity induced by cancer chemotherapeutic agents. In vitro studies of osmotic fragility and methaemoglobin generation.
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Increased osmotic fragility and methaemoglobin generation in vitro have resulted from the exposure of normal human erythrocytes to numerous cancer chemotherapeutic agents. These findings offer a possible explanation for the earlier, consistent clinical observation of the rapid development of anaemia, during consolidation therapy, in children with acute lymphoblastic leukaemia in remission.
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