Early relapse of acute lymphoblastic leukemia is not predictable by serial biochemical assays of terminal transferase activity in cells from peripheral blood
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Serial samples of peripheral blood were collected from 37 children with acute lymphoblastic leukemia (ALL) in remission. Activity of terminal transferase (TdT) was assayed by a biochemical technique. False positive results were obtained infrequently (approx. 1%), in contrast to experience with bone marrow analyses. However, early relapse of disease was not predictable in ALL by repeated measurement of TdT in circulating mononuclear cells during remission.
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