Journal article
Regulation of Pyruvate Dehydrogenase (PDH) Activity in Human Skeletal Muscle During Exercise
Abstract
Pyruvate dehydrogenase is a mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A and regulates the entry of carbohydrate into the tricarboxylic acid cycle for oxidation. During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent VO2max) and is regulated by increases in Ca2+, free ADP, and pyruvate concentrations.
Authors
Spriet LL; Heigenhauser GJF
Journal
Exercise and Sport Sciences Reviews, Vol. 30, No. 2, pp. 91–95
Publisher
Wolters Kluwer
Publication Date
April 2002
DOI
10.1097/00003677-200204000-00009
ISSN
0091-6331