Urticaria from allergy to a purified human anti‐Rh antibody preparation Journal Articles

abstract

• This case presentation describes a young woman who developed generalized urticaria after receiving the human anti‐RhD(D) preparation, WinRho, intravenously. Allergy skin tests and the radioallergosorbent test (RAST) for IgE antibodies to the human anti‐D immunoglobulin preparation were positive. Further studies using high‐pressure liquid chromatography and protein A column chromatography implicated a nonimmunoglobulin low‐molecular‐weight contaminant. This case report illustrates an allergic reaction to a highly purified human immunoglobulin preparation, and demonstrates approaches to assessment of such a reaction.

authors

• Sulakvelidze, I
• Evans, S
• Switzer, I
• Underdown, B
• Greenbaum, Joseph
• Dolovich, J

status

• published 

publication date

• December 1995

has subject area

• Adult (MeSH)
• Canada (MeSH)
• Drug Contamination (MeSH)
• Female (MeSH)
• Humans (MeSH)
• Immunoglobulin E (MeSH)
• Isoantibodies (MeSH)
• Radioallergosorbent Test (MeSH)
• Rh-Hr Blood-Group System (MeSH)
• Rho(D) Immune Globulin (MeSH)
• Skin Tests (MeSH)
• Urticaria (MeSH)

published in

• Acta Allergologica  Journal

keywords

• Adult
• Canada
• Drug Contamination
• Female
• Humans
• Immunoglobulin E
• Isoantibodies
• Radioallergosorbent Test
• Rh-Hr Blood-Group System
• Rho(D) Immune Globulin
• Skin Tests
• Urticaria

Digital Object Identifier (DOI)

• 10.1111/j.1398-9995.1995.tb02511.x

PubMed ID

• 8834828

start page

• 981

end page

• 983

volume

• 50

issue

• 12