Journal article
Role of inositol phospholipid hydrolysis in the initiation of agonist-induced contractions of rat uterus: effects of domination by 17-estradiol and progesterone
Abstract
The role of inositol phospholipid (IP) hydrolysis in agonist-mediated contractility was examined in rat uterine smooth muscle by comparing carbachol-, oxytocin-, and PGF2 alpha-mediated [3H]IP accumulation and tension generation. In both estrogen- and progesterone-dominated uteri, all three agonists exhibited dose-dependent contractile responses. Agonist potencies (EC50 values) for eliciting [3H]IP accumulation or contractile responses were …
Authors
Ruzycky AL; Crankshaw DJ
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 66, No. 1, pp. 10–17
Publisher
Canadian Science Publishing
Publication Date
January 1, 1988
DOI
10.1139/y88-002
ISSN
0008-4212