Journal article
The immunodepletion of factor VII from human plasma using a monoclonal antibody
Abstract
A murine hybridoma cell line which secretes monoclonal antibody to factor VII has been prepared to facilitate the immunodepletion of this clotting factor from plasma. Specific monoclonal antibody was purified from mouse ascites tumours by protein A-Sepharose chromatography and shown to be of the IgG1 immunoglobulin subclass. On immunoblotting, this antibody reacted with a single protein band identical to purified factor VII. The purified …
Authors
Cerskus AL; Ofosu FA; Birchall KJ; Clarke BJ; Modi GJ; Johnston M; Blajchman MA
Journal
British Journal of Haematology, Vol. 61, No. 3, pp. 467–475
Publisher
Wiley
Publication Date
November 1985
DOI
10.1111/j.1365-2141.1985.tb02850.x
ISSN
0007-1048