Journal article
Understanding FVIII/VWF complex – report from a symposium of XXIX WFH meeting 2010
Abstract
von Willebrand factor (VWF) has the capacity to form a complex with factor VIII (FVIII) which may modulate the immunogenicity of FVIII. It has been proposed that a significant fraction of recombinant FVIII (rFVIII) is unable to bind VWF. In an experimental model studied at the McMaster University in Canada, this VWF-unbound rFVIII fraction showed no coagulant function. Sulphation of FVIII tyrosine (Tyr) 1680 has been reported as essential for …
Authors
GRINGERI A; OFOSU FA; GRANCHA S; OLDENBURG J; EWING NP; FEDERICI AB
Journal
Haemophilia, Vol. 18, No. 3, pp. 469–475
Publisher
Wiley
Publication Date
May 2012
DOI
10.1111/j.1365-2516.2011.02655.x
ISSN
1351-8216