Journal article
Beta adrenoreceptor in vascular smooth muscle with special reference to subcellular localization and number of binding sites.
Abstract
The binding of monoiodinated cyanopindolol (ICYP) to membranes from canine and rat aortas, mesenteric arteries and mesenteric nerves has been studied. Binding of ICYP was shown by differential centrifugation and sucrose gradient purification as well as digitonin treatment to be directly related to the content of arterial muscle plasma membrane assessed by marker enzymes. The Kd values obtained were all in the range of 10 to 30 pM but maximum …
Authors
Kwan CY; Sipos SN; Osterroth A; Daniel EE
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 243, No. 3, pp. 1074–1081
Publisher
Elsevier
Publication Date
12 1987
DOI
10.1016/s0022-3565(25)39271-2
ISSN
0022-3565