Excitation-Contraction Coupling in Canine Tracheal Smooth Muscle Cells

In canine tracheal smooth muscle, the significance of depolarization induced by acetylcholine is puzzling because it has no role in contraction. We proposed earlier a model where refilling of ACh-sensitive intracellular Ca2+ stores was in part achieved by a mechanism involving a direct influx of extracellular Ca2+ into the ACh-sensitive Ca2+ store through a dihydropyridine-sensitive channel. Putney proposed that different phases of the calcium …