Journal article
Functional Alterations in the Aorta of the Spontaneously Hypertensive Rat: Pharmacological Assessment with Cyclopiazonic Acid
Abstract
One of the changes in vascular smooth muscle membranes associated with hypertension is an alteration in Ca2+ handling. It has been unclear as to whether changes occurred at the plasma membrane or at the endoplasmic reticulum (ER) or both. Recently, cyclopiazonic acid (CPA) has been reported to inhibit selectively the ER Ca2+ pump. We aimed at determining the effect of ER Ca2+ pump inhibition by CPA on the contractility of aortic smooth muscle …
Authors
Low AM; Kwan CY; Daniel EE
Journal
Pharmacology, Vol. 47, No. 1, pp. 50–60
Publisher
Karger Publishers
Publication Date
July 1993
DOI
10.1159/000139078
ISSN
0031-7012