Journal article
ADP‐stimulated fibrinogen binding is necessary for some of the inositol phospholipid changes found in ADP‐stimulated platelets
Abstract
ADP-stimulation of washed human platelets suspended in Tyrode/albumin solution containing Ca2+ (2 mM) and fibrinogen (0.4 mg/ml) causes extensive, reversible aggregation without appreciable secretion of granule contents. Under these conditions ADP (10 microM) stimulation decreased the amounts of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) and phosphatidylinositol 4-phosphate (PtdInsP) at 10 s. Omitting fibrinogen from the suspending medium …
Authors
VICKERS JD
Journal
The FEBS Journal, Vol. 216, No. 1, pp. 231–237
Publisher
Wiley
Publication Date
August 1993
DOI
10.1111/j.1432-1033.1993.tb18137.x
ISSN
1742-464X