Journal article
Oligopeptides inhibit the ribonucleotide reductase of herpes simplex virus by causing subunit separation
Abstract
It has recently been reported that a nonapeptide (H-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-OH) identical in sequence to the last nine amino acid residues of RR2, the small subunit of herpes simplex virus (HSV) ribonucleotide reductase (E.C. 1.17.4.1; RR), can inhibit HSV RR activity in vitro. It has been postulated that this peptide acts by interfering with the interaction of the large subunit, RR1, and RR2, but direct demonstration of its …
Authors
McClements W; Yamanaka G; Garsky V; Perry H; Bacchetti S; Colonno R; Stein RB
Journal
Virology, Vol. 162, No. 1, pp. 270–273
Publisher
Elsevier
Publication Date
January 1988
DOI
10.1016/0042-6822(88)90421-7
ISSN
0042-6822