Journal article
Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines
Abstract
Acquisition of the immortal phenotype by tumor cells represents an essential and potentially rate-limiting step in tumorigenesis. To identify changes in gene expression that are associated with the early stages of cell immortalization, we compared genetically matched pairs of pre-immortal and immortal human cell clones by mRNA differential display. Two transcripts, denoted CIR1 and CIR2, were identified which were up-regulated in immortal …
Authors
Ma L; Broomfield S; Lavery C; Lin SL; Xiao W; Bacchetti S
Journal
Oncogene, Vol. 17, No. 10, pp. 1321–1326
Publisher
Springer Nature
Publication Date
September 10, 1998
DOI
10.1038/sj.onc.1202058
ISSN
0950-9232