Genetic Variant of Human Erythrocyte Malate Dehydrogenase

MALATE dehydrogenase exists in two distinct forms in a variety of mammalian tissues, one of which is in the cytoplasm as a soluble or supernatant enzyme and the other is tightly bound to the mitochondria1. These two forms have different chemical, physical and kinetic properties2–4 and each has a characteristic electrophoretic pattern5. Unlike most tissues erythrocytes possess only cytoplasmic malato dehydrogenase, as would be expected in the …