The Prostate Cancer Risk Stratification Project: Database Construction and Risk Stratification Outcome Analysis Journal Articles uri icon

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  • This investigation reports on the biochemical and clinical outcomes of a newly created pan-Canadian Prostate Cancer Risk Stratification (ProCaRS) database developed by the Genitourinary Radiation Oncologists of Canada (GUROC). GUROC ProCaRS template-compliant data on 7974 patients who underwent radiotherapy were received from 7 unique databases. Descriptive analysis, Cox proportional hazards, and Kaplan-Meier analyses were performed using American Society for Radiation Oncology (ASTRO) biochemical failure-free survival (BFFS), prostate cancer-specific survival, and overall survival. Multivariable modeling for the primary ASTRO BFFS end point showed that age, prostate-specific antigen, T stage, and Gleason score and components such as hormonal therapy, and radiation treatment (brachytherapy with better outcome than external-beam) were predictive of outcome. Kaplan-Meier analysis of the existing GUROC and new NCCN classification system both showed good separation of all clinical outcome curves. The construction of a pan-Canadian database has informed important prostate cancer radiotherapy outcomes and risk stratification.


  • Rodrigues, George
  • Lukka, Himu
  • Warde, Padraig
  • Brundage, Michael
  • Souhami, Luis
  • Crook, Juanita
  • Cury, Fabio
  • Catton, Charles
  • Mok, Gary
  • Martin, Andre-Guy
  • Vigneault, Eric
  • Morris, Jim
  • Warner, Andrew
  • Maldonado, Sandra Gonzalez
  • Pickles, Tom

publication date

  • January 2014