The expression of interleukin‐6 by a rat macrophage‐derived cell line Journal Articles

abstract

• A stable rat macrophage‐derived cell line (RMSV1) was established by transformation of primary peritoneal exudate cells with the SV40 virus. The RMSV1 cell line was used as a model to study the regulation of the interleukin‐6 (IL6) gene expression in rate macrophages with respect to lipopolysaccharides (LPS), interleukin‐1 (IL1) and glucocorticoids. The IL6 mRNA level in RMSV1 cell lines was induced 20‐fold within 4 h by LPS, whereas IL1 had no effect. The glucocorticoids were able to inhibit completely the induction of the IL6 mRNA synthesis by LPS, indicating the negative regulation of the IL6 gene expression by glucocorticoids.

authors

• Braciak, Todd A
• Gauldie, Jack
• Fey, George H
• Northemann, Wolfgang

status

• published 

publication date

• March 25, 1991

has subject area

• 0304 Medicinal and Biomolecular Chemistry (FoR)
• 0601 Biochemistry and Cell Biology (FoR)
• 0603 Evolutionary Biology (FoR)
• Animals (MeSH)
• Biochemistry & Molecular Biology (Science Metrix)
• Cell Line (MeSH)
• Gene Expression Regulation (MeSH)
• Glucocorticoids (MeSH)
• Interleukin-6 (MeSH)
• Lipopolysaccharides (MeSH)
• Macrophages (MeSH)
• Models, Biological (MeSH)
• Peritoneum (MeSH)
• RNA, Messenger (MeSH)
• Rats (MeSH)

published in

• FEBS Letters  Journal

keywords

• Animals
• Cell Line
• Gene Expression Regulation
• Glucocorticoids
• Interleukin-6
• Lipopolysaccharides
• Macrophages
• Models, Biological
• Peritoneum
• RNA, Messenger
• Rats

Digital Object Identifier (DOI)

• 10.1016/0014-5793(91)80311-p

PubMed ID

• 2013322

start page

• 277

end page

• 280

volume

• 280

issue

• 2