Cortical spreading depression in migraine-time to reconsider? Journal Articles

abstract

• New evidence concerning the pathophysiology of migraine has come from the results of therapeutic transcranial magnetic stimulation (tTMS). The instantaneous responses to single pulses applied during the aura or headache phase, together with a number of other observations, make it unlikely that cortical spreading depression is involved in migraine. tTMS is considered to act by abolishing abnormal impulse activity in cortical pyramidal neurons and a suggestion is made as to how this activity could arise.

authors

• McComas, Alan John
• Upton, Adrian Richard Mainw

status

• published 

publication date

• August 2015

has subject area

• 1103 Clinical Sciences (FoR)
• 1702 Cognitive Sciences (FoR)
• Cerebral Cortex (MeSH)
• Cortical Spreading Depression (MeSH)
• Humans (MeSH)
• Medical Illustration (MeSH)
• Migraine Disorders (MeSH)
• Neurology & Neurosurgery (Science Metrix)
• Neurons (MeSH)
• Transcranial Magnetic Stimulation (MeSH)

published in

• Arquivos de Neuro-Psiquiatria  Journal

keywords

• Cerebral Cortex
• Cortical Spreading Depression
• Humans
• Medical Illustration
• Migraine Disorders
• Neurons
• Transcranial Magnetic Stimulation

Digital Object Identifier (DOI)

• 10.1590/0004-282x20150094

PubMed ID

• 26222365

start page

• 714

end page

• 721

volume

• 73

issue

• 8