ACUTE EFFECTS OF VARYING DOSES OF PROPRANOLOL UPON OXYGEN HAEMOGLOBIN AFFINITY IN MAN Journal Articles uri icon

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abstract

  • The effect of propranolol 2 h following doses of 10, 30, or 100 mg upon the blood oxygen‐haemoglobin dissociation curves has been studied in four normal subjects. The pO2 at 50% saturation (p50) was not changed significantly under control conditions or after 10 and 100 mg doses. There was a just significant increase of 2 mmHg in the p50 value after the 30 mg dose. There was no significant change in red cell adenosine triphosphate or 2, 3‐diphospho‐glycerate nor in plasma phosphate. 4 There was no correlation between plasma propranolol concentration and changes in blood p50.

publication date

  • February 1974