Ethanol Inhibition of Haemoglobin Synthesis: In Vitro Evidence for a Haem Correctable Defect in Normal Subjects and in Alcoholics

S ummary . The effect of ethanol in different concentrations ranging from 0.10 to 0.66 m on globin chain synthesis in vitro was studied by measuring 3 H‐leucine incorporation into human bone marrow suspensions and reticulocyte‐enriched blood. With increasing concentration of ethanol there was a decreasing 3 H‐leucine incorporation. This inhibition was reversed by haem and pyridoxine hydrochloride (PHC) in i mM concentration. 5‐Aminolaevulinic …