Journal article
Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit.
Abstract
We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) …
Authors
Trope GE; Cheng YL; Sheardown H; Liu GS; Menon IA; Heathcote JG; Rootman DS; Chiu WJ; Gould L
Journal
Canadian Journal of Ophthalmology, Vol. 29, No. 6, pp. 263–267
Publication Date
December 1994
ISSN
0008-4182