Journal article
Synthesis of estrogen methyl ethers by extractive alkylation
Abstract
A rapid method for the quantitative preparation of a number of estrogen methyl ethers is described. Estrogen in aqueous base is extracted as an ion pair with the tetrahexylammonium oin into methylene chloride where irreversible alkylation (extractive alkylation) by methyl iodide occurs. Gas chromatography (GC) - mass spectrometry (MS) provided the basis for identification of the methylated products. Estrone (1) and estradiol were easily …
Authors
Daley JD; Rosenfeld JM; YoungLai EV
Journal
Steroids, Vol. 27, No. 4, pp. 481–492
Publisher
Elsevier
Publication Date
April 1976
DOI
10.1016/0039-128x(76)90082-9
ISSN
0039-128X