Journal article
Phenylboronic-Acid-Based Polymeric Micelles for Mucoadhesive Anterior Segment Ocular Drug Delivery
Abstract
Topical drug delivery to the front of the eye is extremely inefficient due to effective natural protection mechanisms such as precorneal tear turnover and the relative impermeability of the cornea and sclera tissues. This causes low ocular drug bioavailability, requiring large frequent doses that result in high systemic exposure and side effects. Mucoadhesive drug delivery systems have the potential to improve topical drug delivery by …
Authors
Prosperi-Porta G; Kedzior S; Muirhead B; Sheardown H
Journal
Biomacromolecules, Vol. 17, No. 4, pp. 1449–1457
Publisher
American Chemical Society (ACS)
Publication Date
April 11, 2016
DOI
10.1021/acs.biomac.6b00054
ISSN
1525-7797