AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells Academic Article uri icon

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abstract

  • AIT-082 is a novel, metabolically stable, derivative of the purine hypoxanthine. Addition of AIT-082 to cultured PC12 cells enhanced significantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore age-induced working memory deficits in mice.

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publication date

  • October 1995