AIT-082, a unique purine derivative, enhances...

AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells

Abstract

AIT-082 is a novel, metabolically stable, derivative of the purine hypoxanthine. Addition of AIT-082 to cultured PC12 cells enhanced significantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore age-induced working memory deficits in mice.

Authors

Middlemiss PJ; Glasky AJ; Rathbone MP; Werstuik E; Hindley S; Gysbers J

Journal

Neuroscience Letters, Vol. 199, No. 2, pp. 131–134

Publisher

Elsevier

Publication Date

October 20, 1995

DOI

10.1016/0304-3940(95)12029-4

ISSN

0304-3940

Associated Experts

Michel Piers Rathbone

Professor, FHSMED

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