Journal article
Spectroscopic evidence of interaction between 2-allyl-2-isopropylacetamide and cytochrome P-450 of rat liver microsomes
Abstract
2-allyl-2-isopropylacetamide (AIA) causes marked induction of heme synthesis in rats and other species, degrades cytochrome P-450 in the presence of NADPH and causes experimental porphyria. Using difference spectroscopy we sought evidence of an interaction between AIA and P-450 in microsomes prepared from rat liver. AIA alone caused small and variable changes in the spectral properties of liver microsomes but markedly inhibited the Type I …
Authors
Sweeney GD; Rothwell JD
Journal
Biochemical and Biophysical Research Communications, Vol. 55, No. 3, pp. 798–804
Publisher
Elsevier
Publication Date
December 1973
DOI
10.1016/0006-291x(73)91214-x
ISSN
0006-291X