From unfractionated heparins to low molecular weight heparins.

Interest in low molecular weight heparins as potential antithrombotic agents has been stimulated by two observations. These were that low molecular weight heparins have a different anticoagulant profile from unfractionated heparin and that some low molecular weight heparins are less haemorrhagic in animal models than unfractionated heparins for equivalent antithrombotic effects. Subsequently, it was shown that low molecular weight heparins …