Journal article
A Low Molecular Weight Heparin Alters the Fetal Coagulation System in the Pregnant Sheep
Abstract
Standard heparin and a LMWH, CY222 do not cross the placenta nor alter fetal coagulation when injected into the pregnant ewe. We found that another LMWH, Pharmuka-10169 (PK-10169) alters fetal coagulation without crossing the placenta in the pregnant sheep. To characterize this anticoagulant we measured the in vitro and in vivo effects of 125I-PK-10169 in maternal and fetal plasmas following administration of PK-10169 to the mother or fetus. …
Authors
Andrew M; Ofosu F; Fernandez F; Jefferies A; Hirsh J; Mitchell L; Buchanan MR
Journal
Thrombosis and Haemostasis, Vol. 55, No. 03, pp. 342–346
Publisher
Thieme
Publication Date
1986
DOI
10.1055/s-0038-1661560
ISSN
0340-6245