Journal article
Evidence for a saturable mechanism of disappearance of standard heparin in rabbits
Abstract
This work demonstrates that after bolus intravenous injection standard heparin (SH) disappearance results from the combination of a saturable and a non saturable mechanism. Pharmacokinetics and pharmacodynamics of SH were studied by measuring the disappearance of increasing doses (5 - 500 anti-factor Xa U/kg) of 125I-heparin and of its biological effects. CPM curves allowed to determine the half lives of heparin according to the dose injected. …
Authors
Boneu B; Caranobe C; Gabaig AM; Dupouy D; Sie P; Buchanan ER; Hirsh J
Journal
Thrombosis Research, Vol. 46, No. 6, pp. 835–844
Publisher
Elsevier
Publication Date
June 1987
DOI
10.1016/0049-3848(87)90075-2
ISSN
0049-3848